Uridine (Uridine 5’-monophosphate) is a nucleotide involved in cell membrane health which supports overall brain function (1, 2).
Uridine Monophosphate Benefits
- Supports cellular membrane health (ref)*
Uridine Monophosphate Mode of Action
Uridine (also known as Uridine Monophosphate) is a nucleotide. It is a necessary substrate in the synthesis of choline. The essential nutrient choline is a building block for the neurotransmitter acetylcholine; and to keep your brain transmitting messages at top-notch speed, you’ll want to keep as much acetylcholine in the body as possible! (3,4)
Unlike choline itself, Uridine has a special advantage due to its relationship with cell membranes. Uridine prevents the release of a harmful acid from the membranes. The release of this acid causes oxidative damage, but Uridine prevents this stress from occurring—something your ordinary choline source can’t do! (3)
Having strong cell membranes (the layer of the cell which controls the entry and transport of cellular nutrients) is one of the most important ways to stay healthy. Uridine has an important part in making and maintaining these cell membranes which keep toxins and intruders from entering the cell (3).
We’ve learned a lot about how Uridine increases the level of choline in the body by studying how it works in animals. It’s part of a complex process where it works as a precursor to making the last step in the choline synthesis pathway which delivers choline straight to neurons where it is converted into acetylcholine (6).
Uridine is a key player in the last step of choline synthesis; but unlike choline, you can’t find much in the food you eat. Humans get their Uridine from breast milk, and then it’s synthesized in the liver after weaning occurs (4)(7).
Stack Uridine with the fish oil fatty acid DHA to increase levels of one of acetylcholine’s building blocks (phosphatidylcholine) by 30%! (4)
Uridine Monophosphate Dosage
Pure Nootropics’ Uridine Monophosphate Capsules provide 250 mg per 1 capsule. Suggested use for adults is 1 capsule (or 250 mg powder weighed on a digital milligram scale) by mouth daily, or as recommended by your healthcare practitioner.
If you are taking any medications, please consult with your healthcare practitioner before beginning supplementation with Uridine Monophosphate.
For further information, please see our References Tab above.